Integrin αIIbβ3 outside-in signaling activates human platelets through serine 24 phosphorylation of Disabled-2

Integrin αIIbβ3 outside-in signaling activates human platelets through serine 24 phosphorylation of Disabled-2

Abstract Background Bidirectional integrin αIIbβ3 signaling is essential for platelet activation. The platelet adaptor protein Disabled-2 (Dab2) is a key regulator of integrin signaling and is phosphorylated at serine 24 in eukaryotic cells. However, the mechanistic insight and function of Dab2-seri...

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Bibliographic Details
Main Authors: Hui-Ju Tsai, Ju-Chien Cheng, Man-Leng Kao, Hung-Pin Chiu, Yi-Hsuan Chiang, Ding-Ping Chen, Kun-Ming Rau, Hsiang-Ruei Liao, Ching-Ping Tseng
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Cell & Bioscience
Subjects:
Disabled-2
Phosphorylation
Platelet activation
Outside-in signaling
Online Access:https://doi.org/10.1186/s13578-021-00532-5

Internet

https://doi.org/10.1186/s13578-021-00532-5

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