Application of Modeling Approaches to Explore Vaccine Adjuvant Mode-of-Action

Application of Modeling Approaches to Explore Vaccine Adjuvant Mode-of-Action

Novel adjuvant technologies have a key role in the development of next-generation vaccines, due to their capacity to modulate the duration, strength and quality of the immune response. The AS01 adjuvant is used in the malaria vaccine RTS,S/AS01 and in the licensed herpes-zoster vaccine (Shingrix) wh...

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Bibliographic Details
Main Authors: Paul R. Buckley, Kieran Alden, Margherita Coccia, Aurélie Chalon, Catherine Collignon, Stéphane T. Temmerman, Arnaud M. Didierlaurent, Robbert van der Most, Jon Timmis, Claus A. Andersen, Mark C. Coles
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
vaccines
adjuvants
mathematical modeling
computational biology
systems biology
mechanistic modeling
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02150/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02150/full

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