USP7 inhibition induces apoptosis in glioblastoma by enhancing ubiquitination of ARF4

USP7 inhibition induces apoptosis in glioblastoma by enhancing ubiquitination of ARF4

Abstract Background Glioblastomas (GBMs) are grade IV central nervous system tumors characterized by a poor prognosis and a short median overall survival. Effective induction of GBM cell death is difficult because the GBM cell population is genetically unstable, resistant to chemotherapy and highly...

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Bibliographic Details
Main Authors: Tingzheng Pan, Xuetao Li, Yanyan Li, Zhennan Tao, Hui Yao, Yue Wu, Guangliang Chen, Kai Zhang, Youxin Zhou, Yulun Huang
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Cancer Cell International
Subjects:
GBM
USP7
Ubiquitination
ARF4
Apoptosis
Online Access:https://doi.org/10.1186/s12935-021-02208-z

Internet

https://doi.org/10.1186/s12935-021-02208-z

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