Alantolactone suppresses inflammation, apoptosis and oxidative stress in cigarette smoke-induced human bronchial epithelial cells through activation of Nrf2/HO-1 and inhibition of the NF-κB pathways

Alantolactone suppresses inflammation, apoptosis and oxidative stress in cigarette smoke-induced human bronchial epithelial cells through activation of Nrf2/HO-1 and inhibition of the NF-κB pathways

Abstract Background It is well established that airway remodeling and inflammation are characteristics for chronic obstructive pulmonary disease (COPD). Moreover, cigarette smoke extract (CSE) promots inflammation, apoptosis and oxidative stress in COPD. And, there is evidence suggested that alantol...

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Bibliographic Details
Main Authors: Xiaomin Dang, Beibei He, Qian Ning, Ya Liu, Jianxin Guo, Gang Niu, Mingwei Chen
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Respiratory Research
Subjects:
Chronic obstructive pulmonary disease
Alantolactone
Cigarette smoke extract
Inflammation
Apoptosis
Oxidative stress
Online Access:http://link.springer.com/article/10.1186/s12931-020-01358-4

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http://link.springer.com/article/10.1186/s12931-020-01358-4

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