Humanized single domain antibodies neutralize SARS-CoV-2 by targeting the spike receptor binding domain

Humanized single domain antibodies neutralize SARS-CoV-2 by targeting the spike receptor binding domain

Here, using a humanized phage display library with recombinant SARS- CoV-2 receptor binding domain (RBD) proteins, the authors identify a number of single domain antibodies (sdAbs) that neutralize SARS-CoV-2 in vitro by inhibiting the interaction of the RDB with the host entry receptor ACE2.

Bibliographic Details
Main Authors: Xiaojing Chi, Xiuying Liu, Conghui Wang, Xinhui Zhang, Xiang Li, Jianhua Hou, Lili Ren, Qi Jin, Jianwei Wang, Wei Yang
Format: Article
Language:English
Published: Nature Publishing Group 2020-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18387-8

Internet

https://doi.org/10.1038/s41467-020-18387-8

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