Heterogeneity of HBV-Specific CD8+ T-Cell Failure: Implications for Immunotherapy

Heterogeneity of HBV-Specific CD8+ T-Cell Failure: Implications for Immunotherapy

Chronic hepatitis B virus (HBV) infection is a major global health burden affecting around 257 million people worldwide. The consequences of chronic HBV infection include progressive liver damage, liver cirrhosis, and hepatocellular carcinoma. Although current direct antiviral therapies successfully...

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Bibliographic Details
Main Authors: Kathrin Heim, Christoph Neumann-Haefelin, Robert Thimme, Maike Hofmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
chronic HBV infection
CD8+ T cells
exhaustion
T-cell heterogeneity
viral antigen
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02240/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02240/full

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