Targeting A20 decreases glioma stem cell survival and tumor growth.

Targeting A20 decreases glioma stem cell survival and tumor growth.

Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioblastoma stem cells (GSCs). GSCs are regulated by molecular pathways distinct from the bulk tumor that may be useful therapeutic targets. We determined that A20 (TNFAIP3), a regulator of cel...

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Bibliographic Details
Main Authors: Anita B Hjelmeland, Qiulian Wu, Sarah Wickman, Christine Eyler, John Heddleston, Qing Shi, Justin D Lathia, Jennifer Macswords, Jeongwu Lee, Roger E McLendon, Jeremy N Rich
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-02-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC2826371?pdf=render

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http://europepmc.org/articles/PMC2826371?pdf=render

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