Targeting A20 decreases glioma stem cell survival and tumor growth.
Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioblastoma stem cells (GSCs). GSCs are regulated by molecular pathways distinct from the bulk tumor that may be useful therapeutic targets. We determined that A20 (TNFAIP3), a regulator of cel...
Main Authors: | Anita B Hjelmeland, Qiulian Wu, Sarah Wickman, Christine Eyler, John Heddleston, Qing Shi, Justin D Lathia, Jennifer Macswords, Jeongwu Lee, Roger E McLendon, Jeremy N Rich |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010-02-01
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Series: | PLoS Biology |
Online Access: | http://europepmc.org/articles/PMC2826371?pdf=render |
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