The Activation Effect of Hainantoxin-I, a Peptide Toxin from the Chinese Spider, Ornithoctonus hainana, on Intermediate-Conductance Ca2+-Activated K+ Channels

The Activation Effect of Hainantoxin-I, a Peptide Toxin from the Chinese Spider, Ornithoctonus hainana, on Intermediate-Conductance Ca2+-Activated K+ Channels

Intermediate-conductance Ca2+-activated K+ (IK) channels are calcium/calmodulin-regulated voltage-independent K+ channels. Activation of IK currents is important in vessel and respiratory tissues, rendering the channels potential drug targets. A variety of small organic molecules have been synthesiz...

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Bibliographic Details
Main Authors: Pengfei Huang, Yiya Zhang, Xinyi Chen, Li Zhu, Dazhong Yin, Xiongzhi Zeng, Songping Liang
Format: Article
Language:English
Published: MDPI AG 2014-08-01
Series:Toxins
Subjects:
IK channels
peptide activator
HNTX-I
selectivity
new drug design
Online Access:http://www.mdpi.com/2072-6651/6/8/2568

Internet

http://www.mdpi.com/2072-6651/6/8/2568

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