Posttranscriptional gene regulation by spatial rearrangement of the 3' untranslated region.
Translation termination at premature termination codons (PTCs) triggers degradation of the aberrant mRNA, but the mechanism by which a termination event is defined as premature is still unclear. Here we show that the physical distance between the termination codon and the poly(A)-binding protein PAB...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2008-04-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC2689704?pdf=render |