Autophagy Activation by Rapamycin Before Hypoxia-Reoxygenation Reduces Endoplasmic Reticulum Stress in Alveolar Epithelial Cells

Autophagy Activation by Rapamycin Before Hypoxia-Reoxygenation Reduces Endoplasmic Reticulum Stress in Alveolar Epithelial Cells

Background: To determine potential effects of autophagy activation on hypoxia-reoxygenation (H/R) induced damage of a rat alveolar epithelial cell line. Methods: CCL149 cells were subjected to autophagy agonist (rapamycin, Rap), autophagy inhibitor (3-methyladenine, 3-MA) or PBS for 1 h before H/R t...

Full description

Bibliographic Details
Main Authors: Tao Fan, Lei Chen, Zhixin Huang, Wei Wang, Boyou Zhang, Yao Xu, Zhangfan Mao, Hao Hu, Qing Geng
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-01-01
Series:Cellular Physiology and Biochemistry
Subjects:
Alveolar hypoxia-reoxygenation
Autophagy
Unfolded protein response
Endoplasmatic reticulum stress
Rapamycin
Online Access:http://www.karger.com/Article/FullText/455953

Internet

http://www.karger.com/Article/FullText/455953

Similar Items