The GAUGAA Motif Is Responsible for the Binding between circSMARCA5 and SRSF1 and Related Downstream Effects on Glioblastoma Multiforme Cell Migration and Angiogenic Potential

The GAUGAA Motif Is Responsible for the Binding between circSMARCA5 and SRSF1 and Related Downstream Effects on Glioblastoma Multiforme Cell Migration and Angiogenic Potential

Circular RNAs (circRNAs) are a large class of RNAs with regulatory functions within cells. We recently showed that circSMARCA5 is a tumor suppressor in glioblastoma multiforme (GBM) and acts as a decoy for Serine and Arginine Rich Splicing Factor 1 (SRSF1) through six predicted binding sites (BSs)....

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Bibliographic Details
Main Authors: Davide Barbagallo, Angela Caponnetto, Cristina Barbagallo, Rosalia Battaglia, Federica Mirabella, Duilia Brex, Michele Stella, Giuseppe Broggi, Roberto Altieri, Francesco Certo, Rosario Caltabiano, Giuseppe Maria Vincenzo Barbagallo, Carmelina Daniela Anfuso, Gabriella Lupo, Marco Ragusa, Cinzia Di Pietro, Thomas Birkballe Hansen, Michele Purrello
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
circSMARCA5
RNA-binding proteins
SRSF1
VEGFA
SRSF3
binding site mutation
Online Access:https://www.mdpi.com/1422-0067/22/4/1678

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https://www.mdpi.com/1422-0067/22/4/1678

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