The Use of Computational Approaches in the Discovery and Mechanism Study of Opioid Analgesics

The Use of Computational Approaches in the Discovery and Mechanism Study of Opioid Analgesics

Opioid receptors that belong to class A G protein-coupled receptors (GPCRs) are vital in pain control. In the past few years, published high-resolution crystal structures of opioid receptor laid a solid basis for both experimental and computational studies. Computer-aided drug design (CADD) has been...

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Bibliographic Details
Main Authors: Bangyi Zhao, Wei Li, Lijie Sun, Wei Fu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Chemistry
Subjects:
opioid receptor
analgesics
computer-aided drug design
molecular dynamics
agonist mechanism
G-protein-biased activation
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2020.00335/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2020.00335/full

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