DNA methylation impacts gene expression and ensures hypoxic survival of Mycobacterium tuberculosis.

DNA methylation regulates gene expression in many organisms. In eukaryotes, DNA methylation is associated with gene repression, while it exerts both activating and repressive effects in the Proteobacteria through largely locus-specific mechanisms. Here, we identify a critical DNA methyltransferase i...

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Bibliographic Details
Main Authors: Scarlet S Shell, Erin G Prestwich, Seung-Hun Baek, Rupal R Shah, Christopher M Sassetti, Peter C Dedon, Sarah M Fortune
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3701705?pdf=render