Discovering Genetic Interactions in Large-Scale Association Studies by Stage-wise Likelihood Ratio Tests.

Despite the success of genome-wide association studies in medical genetics, the underlying genetics of many complex diseases remains enigmatic. One plausible reason for this could be the failure to account for the presence of genetic interactions in current analyses. Exhaustive investigations of int...

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Bibliographic Details
Main Authors: Mattias Frånberg, Karl Gertow, Anders Hamsten, PROCARDIS consortium, Jens Lagergren, Bengt Sennblad
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-09-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4581725?pdf=render