RFWD2 Knockdown as a Blocker to Reverse the Oncogenic Role of TRIB2 in Lung Adenocarcinoma

RFWD2 Knockdown as a Blocker to Reverse the Oncogenic Role of TRIB2 in Lung Adenocarcinoma

RFWD2, an E3 ubiquitin ligase, is overexpressed in numerous human cancers, including leukemia, lung cancer, breast cancer, renal cell carcinoma, and colorectal cancer. The roles of RFWD2 in cancer are related to the targeting of its substrates for ubiquitination and degradation. This study aimed to...

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Bibliographic Details
Main Authors: Ruimin Hao, Jinxia Hu, Yuemei Liu, Dongmin Liang, Yan-Mei Li, Ranran Wang, Shucui Zhang, Pingyu Wang, You-Jie Li, Shuyang Xie
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Oncology
Subjects:
RFWD2
proteasome-mediated degradation
TRIB2
cancer therapy
target gene
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.733175/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.733175/full

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