Dysregulation of Astrocytic HMGB1 Signaling in Amyotrophic Lateral Sclerosis

Astrocytes have emerged as critical elements for the maintenance and function of the central nervous system. The expression on their cell membrane of RAGE and TLR4 receptors makes astrocytes susceptible to High-mobility group box 1 (HMGB1), a nuclear protein typically released in the extracellular m...

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Bibliographic Details
Main Authors: Liliana Brambilla, Francesca Martorana, Giulia Guidotti, Daniela Rossi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Neuroscience
Subjects:
ALS
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00622/full