High-resolution structure of the amino acid transporter AdiC reveals insights into the role of water molecules and networks in oligomerization and substrate binding

High-resolution structure of the amino acid transporter AdiC reveals insights into the role of water molecules and networks in oligomerization and substrate binding

Abstract Background The L-arginine/agmatine transporter AdiC is part of the arginine-dependent extreme acid resistance system of the bacterium Escherichia coli and its pathogenic varieties such as strain E. coli O157:H7. At the present time, there is a lack of knowledge concerning the role of water...

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Bibliographic Details
Main Authors: Hüseyin Ilgü, Jean-Marc Jeckelmann, David Kalbermatter, Zöhre Ucurum, Thomas Lemmin, Dimitrios Fotiadis
Format: Article
Language:English
Published: BMC 2021-08-01
Series:BMC Biology
Subjects:
AdiC
Amino acid transporter
Crystal structure
Membrane protein
Molecular dynamics simulations
Water networks
Online Access:https://doi.org/10.1186/s12915-021-01102-4

Internet

https://doi.org/10.1186/s12915-021-01102-4

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