Frequency and prognostic impact of CEBPA proximal, distal and core promoter methylation in normal karyotype AML: a study on 623 cases.

Frequency and prognostic impact of CEBPA proximal, distal and core promoter methylation in normal karyotype AML: a study on 623 cases.

The clinical impact of aberrant CEBPA promoter methylation (PM) in AML is controversially discussed. The aim of this study was to clarify the significance of aberrant CEBPA PM with regard to clinical features in a cohort of 623 cytogenetically normal (CN) de novo AML. 555 cases had wild-type CEBPA,...

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Bibliographic Details
Main Authors: Annette Fasan, Tamara Alpermann, Claudia Haferlach, Vera Grossmann, Andreas Roller, Alexander Kohlmann, Christiane Eder, Wolfgang Kern, Torsten Haferlach, Susanne Schnittger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3562230?pdf=render

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http://europepmc.org/articles/PMC3562230?pdf=render

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