Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator

Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator

Although many genetic variants are known for obesity, their function remains largely unknown. Here, in a weight-loss intervention cohort, the authors identify protein quantitative trait loci associated with BMI at baseline and after weight loss and find FAM46A to be a regulator of leptin in adipocyt...

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Main Authors: Jérôme Carayol, Christian Chabert, Alessandro Di Cara, Claudia Armenise, Gregory Lefebvre, Dominique Langin, Nathalie Viguerie, Sylviane Metairon, Wim H. M. Saris, Arne Astrup, Patrick Descombes, Armand Valsesia, Jörg Hager
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02182-z
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spelling doaj-5a5fba936b994740abf88acab0a29fef2021-05-11T07:26:17ZengNature Publishing GroupNature Communications2041-17232017-12-018111410.1038/s41467-017-02182-zProtein quantitative trait locus study in obesity during weight-loss identifies a leptin regulatorJérôme Carayol0Christian Chabert1Alessandro Di Cara2Claudia Armenise3Gregory Lefebvre4Dominique Langin5Nathalie Viguerie6Sylviane Metairon7Wim H. M. Saris8Arne Astrup9Patrick Descombes10Armand Valsesia11Jörg Hager12Nestlé Institute of Health Sciences, EPFL Innovation ParkNestlé Institute of Health Sciences, EPFL Innovation ParkQuartz BioQuartz BioNestlé Institute of Health Sciences, EPFL Innovation ParkINSERM UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, University of ToulouseINSERM UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, University of ToulouseNestlé Institute of Health Sciences, EPFL Innovation ParkDepartment of Human Biology, NUTRIM, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical CentreDepartment of Nutrition, Exercise and Sports, Faculty of Science, University of CopenhagenNestlé Institute of Health Sciences, EPFL Innovation ParkNestlé Institute of Health Sciences, EPFL Innovation ParkNestlé Institute of Health Sciences, EPFL Innovation ParkAlthough many genetic variants are known for obesity, their function remains largely unknown. Here, in a weight-loss intervention cohort, the authors identify protein quantitative trait loci associated with BMI at baseline and after weight loss and find FAM46A to be a regulator of leptin in adipocytes.https://doi.org/10.1038/s41467-017-02182-z
collection DOAJ
language English
format Article
sources DOAJ
author Jérôme Carayol
Christian Chabert
Alessandro Di Cara
Claudia Armenise
Gregory Lefebvre
Dominique Langin
Nathalie Viguerie
Sylviane Metairon
Wim H. M. Saris
Arne Astrup
Patrick Descombes
Armand Valsesia
Jörg Hager
spellingShingle Jérôme Carayol
Christian Chabert
Alessandro Di Cara
Claudia Armenise
Gregory Lefebvre
Dominique Langin
Nathalie Viguerie
Sylviane Metairon
Wim H. M. Saris
Arne Astrup
Patrick Descombes
Armand Valsesia
Jörg Hager
Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator
Nature Communications
author_facet Jérôme Carayol
Christian Chabert
Alessandro Di Cara
Claudia Armenise
Gregory Lefebvre
Dominique Langin
Nathalie Viguerie
Sylviane Metairon
Wim H. M. Saris
Arne Astrup
Patrick Descombes
Armand Valsesia
Jörg Hager
author_sort Jérôme Carayol
title Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator
title_short Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator
title_full Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator
title_fullStr Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator
title_full_unstemmed Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator
title_sort protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-12-01
description Although many genetic variants are known for obesity, their function remains largely unknown. Here, in a weight-loss intervention cohort, the authors identify protein quantitative trait loci associated with BMI at baseline and after weight loss and find FAM46A to be a regulator of leptin in adipocytes.
url https://doi.org/10.1038/s41467-017-02182-z
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