Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator
Although many genetic variants are known for obesity, their function remains largely unknown. Here, in a weight-loss intervention cohort, the authors identify protein quantitative trait loci associated with BMI at baseline and after weight loss and find FAM46A to be a regulator of leptin in adipocyt...
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2017-12-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-017-02182-z |
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doaj-5a5fba936b994740abf88acab0a29fef2021-05-11T07:26:17ZengNature Publishing GroupNature Communications2041-17232017-12-018111410.1038/s41467-017-02182-zProtein quantitative trait locus study in obesity during weight-loss identifies a leptin regulatorJérôme Carayol0Christian Chabert1Alessandro Di Cara2Claudia Armenise3Gregory Lefebvre4Dominique Langin5Nathalie Viguerie6Sylviane Metairon7Wim H. M. Saris8Arne Astrup9Patrick Descombes10Armand Valsesia11Jörg Hager12Nestlé Institute of Health Sciences, EPFL Innovation ParkNestlé Institute of Health Sciences, EPFL Innovation ParkQuartz BioQuartz BioNestlé Institute of Health Sciences, EPFL Innovation ParkINSERM UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, University of ToulouseINSERM UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, University of ToulouseNestlé Institute of Health Sciences, EPFL Innovation ParkDepartment of Human Biology, NUTRIM, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical CentreDepartment of Nutrition, Exercise and Sports, Faculty of Science, University of CopenhagenNestlé Institute of Health Sciences, EPFL Innovation ParkNestlé Institute of Health Sciences, EPFL Innovation ParkNestlé Institute of Health Sciences, EPFL Innovation ParkAlthough many genetic variants are known for obesity, their function remains largely unknown. Here, in a weight-loss intervention cohort, the authors identify protein quantitative trait loci associated with BMI at baseline and after weight loss and find FAM46A to be a regulator of leptin in adipocytes.https://doi.org/10.1038/s41467-017-02182-z |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jérôme Carayol Christian Chabert Alessandro Di Cara Claudia Armenise Gregory Lefebvre Dominique Langin Nathalie Viguerie Sylviane Metairon Wim H. M. Saris Arne Astrup Patrick Descombes Armand Valsesia Jörg Hager |
spellingShingle |
Jérôme Carayol Christian Chabert Alessandro Di Cara Claudia Armenise Gregory Lefebvre Dominique Langin Nathalie Viguerie Sylviane Metairon Wim H. M. Saris Arne Astrup Patrick Descombes Armand Valsesia Jörg Hager Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator Nature Communications |
author_facet |
Jérôme Carayol Christian Chabert Alessandro Di Cara Claudia Armenise Gregory Lefebvre Dominique Langin Nathalie Viguerie Sylviane Metairon Wim H. M. Saris Arne Astrup Patrick Descombes Armand Valsesia Jörg Hager |
author_sort |
Jérôme Carayol |
title |
Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator |
title_short |
Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator |
title_full |
Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator |
title_fullStr |
Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator |
title_full_unstemmed |
Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator |
title_sort |
protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2017-12-01 |
description |
Although many genetic variants are known for obesity, their function remains largely unknown. Here, in a weight-loss intervention cohort, the authors identify protein quantitative trait loci associated with BMI at baseline and after weight loss and find FAM46A to be a regulator of leptin in adipocytes. |
url |
https://doi.org/10.1038/s41467-017-02182-z |
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