Sildenafil Reduces Expression and Release of IL-6 and IL-8 Induced by Reactive Oxygen Species in Systemic Sclerosis Fibroblasts

Sildenafil Reduces Expression and Release of IL-6 and IL-8 Induced by Reactive Oxygen Species in Systemic Sclerosis Fibroblasts

Oxidative stress linked to vascular damage plays an important role in the pathogenesis of systemic sclerosis (SSc). Indeed, vascular damage at nailfold capillaroscopy in patients with Raynaud’s Phenomenon (RP) is a major risk factor for the development of SSc together with the presence of specific a...

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Bibliographic Details
Main Authors: Luigi Di Luigi, Paolo Sgrò, Guglielmo Duranti, Stefania Sabatini, Daniela Caporossi, Francesco Del Galdo, Ivan Dimauro, Cristina Antinozzi
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
systemic sclerosis
oxidative stress
inflammation
PDE5 inhibitors
Online Access:https://www.mdpi.com/1422-0067/21/9/3161

Internet

https://www.mdpi.com/1422-0067/21/9/3161

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