T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells
CD4 T cell polarizations and functions are regulated by cytokines from innate cells. Here the authors show that IL-1 deficiency does not impair the differentiation of Th1, Th2 and Th17, but IL-1 signaling is required for maintaining the expressions of their respective key cytokines to ‘license’ the...
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Nature Publishing Group
2018-08-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-05489-7 |
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doaj-5a633d6c97f64ce594f648e00b0e65742021-05-11T10:22:59ZengNature Publishing GroupNature Communications2041-17232018-08-019111310.1038/s41467-018-05489-7T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cellsAakanksha Jain0Ran Song1Edward K. Wakeland2Chandrashekhar Pasare3Department of Immunology, University of Texas Southwestern Medical CenterDepartment of Immunology, University of Texas Southwestern Medical CenterDepartment of Immunology, University of Texas Southwestern Medical CenterDepartment of Immunology, University of Texas Southwestern Medical CenterCD4 T cell polarizations and functions are regulated by cytokines from innate cells. Here the authors show that IL-1 deficiency does not impair the differentiation of Th1, Th2 and Th17, but IL-1 signaling is required for maintaining the expressions of their respective key cytokines to ‘license’ the functions of these T cell subsets.https://doi.org/10.1038/s41467-018-05489-7 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aakanksha Jain Ran Song Edward K. Wakeland Chandrashekhar Pasare |
spellingShingle |
Aakanksha Jain Ran Song Edward K. Wakeland Chandrashekhar Pasare T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells Nature Communications |
author_facet |
Aakanksha Jain Ran Song Edward K. Wakeland Chandrashekhar Pasare |
author_sort |
Aakanksha Jain |
title |
T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells |
title_short |
T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells |
title_full |
T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells |
title_fullStr |
T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells |
title_full_unstemmed |
T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells |
title_sort |
t cell-intrinsic il-1r signaling licenses effector cytokine production by memory cd4 t cells |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2018-08-01 |
description |
CD4 T cell polarizations and functions are regulated by cytokines from innate cells. Here the authors show that IL-1 deficiency does not impair the differentiation of Th1, Th2 and Th17, but IL-1 signaling is required for maintaining the expressions of their respective key cytokines to ‘license’ the functions of these T cell subsets. |
url |
https://doi.org/10.1038/s41467-018-05489-7 |
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