T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells

T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells

CD4 T cell polarizations and functions are regulated by cytokines from innate cells. Here the authors show that IL-1 deficiency does not impair the differentiation of Th1, Th2 and Th17, but IL-1 signaling is required for maintaining the expressions of their respective key cytokines to ‘license’ the...

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Main Authors: Aakanksha Jain, Ran Song, Edward K. Wakeland, Chandrashekhar Pasare
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05489-7
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spelling doaj-5a633d6c97f64ce594f648e00b0e65742021-05-11T10:22:59ZengNature Publishing GroupNature Communications2041-17232018-08-019111310.1038/s41467-018-05489-7T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cellsAakanksha Jain0Ran Song1Edward K. Wakeland2Chandrashekhar Pasare3Department of Immunology, University of Texas Southwestern Medical CenterDepartment of Immunology, University of Texas Southwestern Medical CenterDepartment of Immunology, University of Texas Southwestern Medical CenterDepartment of Immunology, University of Texas Southwestern Medical CenterCD4 T cell polarizations and functions are regulated by cytokines from innate cells. Here the authors show that IL-1 deficiency does not impair the differentiation of Th1, Th2 and Th17, but IL-1 signaling is required for maintaining the expressions of their respective key cytokines to ‘license’ the functions of these T cell subsets.https://doi.org/10.1038/s41467-018-05489-7
collection DOAJ
language English
format Article
sources DOAJ
author Aakanksha Jain
Ran Song
Edward K. Wakeland
Chandrashekhar Pasare
spellingShingle Aakanksha Jain
Ran Song
Edward K. Wakeland
Chandrashekhar Pasare
T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells
Nature Communications
author_facet Aakanksha Jain
Ran Song
Edward K. Wakeland
Chandrashekhar Pasare
author_sort Aakanksha Jain
title T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells
title_short T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells
title_full T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells
title_fullStr T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells
title_full_unstemmed T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells
title_sort t cell-intrinsic il-1r signaling licenses effector cytokine production by memory cd4 t cells
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-08-01
description CD4 T cell polarizations and functions are regulated by cytokines from innate cells. Here the authors show that IL-1 deficiency does not impair the differentiation of Th1, Th2 and Th17, but IL-1 signaling is required for maintaining the expressions of their respective key cytokines to ‘license’ the functions of these T cell subsets.
url https://doi.org/10.1038/s41467-018-05489-7
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AT edwardkwakeland tcellintrinsicil1rsignalinglicenseseffectorcytokineproductionbymemorycd4tcells
AT chandrashekharpasare tcellintrinsicil1rsignalinglicenseseffectorcytokineproductionbymemorycd4tcells
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