A Novel HDL-Mimetic Peptide HM-10/10 Protects RPE and Photoreceptors in Murine Models of Retinal Degeneration

A Novel HDL-Mimetic Peptide HM-10/10 Protects RPE and Photoreceptors in Murine Models of Retinal Degeneration

Age-related macular degeneration (AMD) is a leading cause of blindness in the developed world. The retinal pigment epithelium (RPE) is a critical site of pathology in AMD. Oxidative stress plays a key role in the development of AMD. We generated a chimeric high-density lipoprotein (HDL), mimetic pep...

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Bibliographic Details
Main Authors: Feng Su, Christine Spee, Eduardo Araujo, Eric Barron, Mo Wang, Caleb Ghione, David R. Hinton, Steven Nusinowitz, Ram Kannan, Srinivasa T. Reddy, Robin Farias-Eisner
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
retinal pigment epithelium (rpe)
sodium iodate
geographic atrophy
retinitis pigmentosa
apoptosis
hdl-mimetic peptide
oct
retinal function
Online Access:https://www.mdpi.com/1422-0067/20/19/4807

Internet

https://www.mdpi.com/1422-0067/20/19/4807

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