Revealing Spatial and Temporal Patterns of Cell Death, Glial Proliferation, and Blood-Brain Barrier Dysfunction Around Implanted Intracortical Neural Interfaces

Revealing Spatial and Temporal Patterns of Cell Death, Glial Proliferation, and Blood-Brain Barrier Dysfunction Around Implanted Intracortical Neural Interfaces

Improving the long-term performance of neural electrode interfaces requires overcoming severe biological reactions such as neuronal cell death, glial cell activation, and vascular damage in the presence of implanted intracortical devices. Past studies traditionally observe neurons, microglia, astroc...

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Bibliographic Details
Main Authors: Steven M. Wellman, Lehong Li, Yalikun Yaxiaer, Ingrid McNamara, Takashi D. Y. Kozai
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Neuroscience
Subjects:
oligodendrocytes
NG2 glia
pericytes
tissue-electrode interface
neurodegeneration
gliosis
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00493/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.00493/full

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