Quercetin 3,5,7,3′,4′-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1

Quercetin 3,5,7,3′,4′-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1

A compound from Thai black ginger, KPMF-8, was previously found to dramatically promote activation of SIRT1 towards a peptide substrate. Zhang et al. now show that KPMF-8 can be taken up by cells through culture media, directly interacts with SIRT1, and promotes its deacetylation activity toward nat...

Full description

Bibliographic Details
Main Authors: Mimin Zhang, Peng Lu, Tohru Terada, Miaomiao Sui, Haruka Furuta, Kilico Iida, Yukie Katayama, Yi Lu, Ken Okamoto, Michio Suzuki, Tomiko Asakura, Kentaro Shimizu, Fumihiko Hakuno, Shin-Ichiro Takahashi, Norimoto Shimada, Jinwei Yang, Tsutomu Ishikawa, Jin Tatsuzaki, Koji Nagata
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-01705-1

Internet

https://doi.org/10.1038/s42003-021-01705-1

Similar Items