Tumor-Derived Extracellular Vesicles Inhibit Natural Killer Cell Function in Pancreatic Cancer

Tumor-Derived Extracellular Vesicles Inhibit Natural Killer Cell Function in Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies. Tumor-derived extracellular vesicles (EVs) induce pre-metastatic niche formation to promote metastasis. We isolated EVs from a highly-metastatic pancreatic cancer cell line and patient-derived primary cancer cells by ult...

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Bibliographic Details
Main Authors: Jiangang Zhao, Hans A. Schlößer, Zhefang Wang, Jie Qin, Jiahui Li, Felix Popp, Marie Christine Popp, Hakan Alakus, Seung-Hun Chon, Hinrich P. Hansen, Wolfram F. Neiss, Karl-Walter Jauch, Christiane J. Bruns, Yue Zhao
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cancers
Subjects:
extracellular vesicles
NK cells
pancreatic cancer
pre-metastatic niche
Online Access:https://www.mdpi.com/2072-6694/11/6/874

Internet

https://www.mdpi.com/2072-6694/11/6/874

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