COVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system

COVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system

The SARS-CoV-2 receptor ACE2 is involved in the Renin-Angiotensin-Aldosterone System (RAAS). Over-activation of RAAS in swine results in a disease state similar to that of COVID-19 in human patients, suggesting that COVID-19 pathophysiology may be driven, at least in part, by an imbalance of this ho...

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Bibliographic Details
Main Authors: Susanne Rysz, Jonathan Al-Saadi, Anna Sjöström, Maria Farm, Francesca Campoccia Jalde, Michael Plattén, Helen Eriksson, Margareta Klein, Roberto Vargas-Paris, Sven Nyrén, Goran Abdula, Russell Ouellette, Tobias Granberg, Malin Jonsson Fagerlund, Johan Lundberg
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22713-z

Internet

https://doi.org/10.1038/s41467-021-22713-z

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