Functional analysis of BARD1 missense variants in homology-directed repair and damage sensitivity.

Functional analysis of BARD1 missense variants in homology-directed repair and damage sensitivity.

The BARD1 protein, which heterodimerizes with BRCA1, is encoded by a known breast cancer susceptibility gene. While several BARD1 variants have been identified as pathogenic, many more missense variants exist that do not occur frequently enough to assign a clinical risk. In this paper, whole exome s...

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Bibliographic Details
Main Authors: Aleksandra I Adamovich, Tapahsama Banerjee, Margaret Wingo, Kathryn Duncan, Jie Ning, Fernanda Martins Rodrigues, Kuan-Lin Huang, Cindy Lee, Feng Chen, Li Ding, Jeffrey D Parvin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-03-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC6457558?pdf=render

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http://europepmc.org/articles/PMC6457558?pdf=render

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