Bone Morphogenetic Protein 9 Protects against Neonatal Hyperoxia-Induced Impairment of Alveolarization and Pulmonary Inflammation

Bone Morphogenetic Protein 9 Protects against Neonatal Hyperoxia-Induced Impairment of Alveolarization and Pulmonary Inflammation

Aim: Effective treatment of premature infants with bronchopulmonary dysplasia (BPD) is lacking. We hypothesize that bone morphogenetic protein 9 (BMP9), a ligand of the TGF-β family that binds to the activin receptor-like kinase 1 (ALK1)-BMP receptor type 2 (BMPR2) receptor complex, may be a novel t...

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Bibliographic Details
Main Authors: Xueyu Chen, Mar Orriols, Frans J. Walther, El Houari Laghmani, Annemarie M. Hoogeboom, Anne C. B. Hogen-Esch, Pieter S. Hiemstra, Gert Folkerts, Marie-José T. H. Goumans, Peter ten Dijke, Nicholas W. Morrell, Gerry T. M. Wagenaar
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Physiology
Subjects:
bronchopulmonary dysplasia
lung fibrosis
activin receptor-like kinase 1
right ventricular hypertrophy
transmembrane protein 100
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00486/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00486/full

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