Prenatal methadone exposure disrupts behavioral development and alters motor neuron intrinsic properties and local circuitry

Prenatal methadone exposure disrupts behavioral development and alters motor neuron intrinsic properties and local circuitry

Despite the rising prevalence of methadone treatment in pregnant women with opioid use disorder, the effects of methadone on neurobehavioral development remain unclear. We developed a translational mouse model of prenatal methadone exposure (PME) that resembles the typical pattern of opioid use by p...

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Bibliographic Details
Main Authors: Gregory G Grecco, Briana E Mork, Jui-Yen Huang, Corinne E Metzger, David L Haggerty, Kaitlin C Reeves, Yong Gao, Hunter Hoffman, Simon N Katner, Andrea R Masters, Cameron W Morris, Erin A Newell, Eric A Engleman, Anthony J Baucum, Jiuen Kim, Bryan K Yamamoto, Matthew R Allen, Yu-Chien Wu, Hui-Chen Lu, Patrick L Sheets, Brady K Atwood
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-03-01
Series:eLife
Subjects:
prenatal opioid
development
behavior
motor cortex
Online Access:https://elifesciences.org/articles/66230

Internet

https://elifesciences.org/articles/66230

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