In vitro screening for acetylcholinesterase and butyrylcholinesterase inhibition and antimicrobial activity of chia seeds (Salvia hispanica)
Background: Chia seeds are gaining increasing interest among food producers and consumers because of their prohealth properties. Results: The aim of this work was to evaluate the potential of chia seeds to act as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. The highest in...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2019-01-01
|
Series: | Electronic Journal of Biotechnology |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0717345818300411 |
id |
doaj-5a7bf16d6f374d8e97819a1529d7cd44 |
---|---|
record_format |
Article |
spelling |
doaj-5a7bf16d6f374d8e97819a1529d7cd442020-11-25T00:10:46ZengElsevierElectronic Journal of Biotechnology0717-34582019-01-0137110In vitro screening for acetylcholinesterase and butyrylcholinesterase inhibition and antimicrobial activity of chia seeds (Salvia hispanica)Joanna Kobus-Cisowska0Daria Szymanowska1Paulina Maciejewska2Dominik Kmiecik3Anna Gramza-Michałowska4Bartosz Kulczyński5Judyta Cielecka-Piontek6Faculty of Food Science and Nutrition, Poznań University of Life Sciences, ul. Wojska Polskiego 31, 60-634 Poznań, PolandFaculty of Food Science and Nutrition, Poznań University of Life Sciences, ul. Wojska Polskiego 31, 60-634 Poznań, Poland; Corresponding author.Faculty of Food Science and Nutrition, Poznań University of Life Sciences, ul. Wojska Polskiego 31, 60-634 Poznań, PolandFaculty of Food Science and Nutrition, Poznań University of Life Sciences, ul. Wojska Polskiego 31, 60-634 Poznań, PolandFaculty of Food Science and Nutrition, Poznań University of Life Sciences, ul. Wojska Polskiego 31, 60-634 Poznań, PolandFaculty of Food Science and Nutrition, Poznań University of Life Sciences, ul. Wojska Polskiego 31, 60-634 Poznań, PolandDepartment of Pharmaceutical Chemistry, Poznań University of Medical Sciences, ul. Grunwaldzka 6, 60-780 Poznań, PolandBackground: Chia seeds are gaining increasing interest among food producers and consumers because of their prohealth properties. Results: The aim of this work was to evaluate the potential of chia seeds to act as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. The highest inhibitory activity against AChE and BChE was observed for colored seed ethanol extracts. A positive correlation was found between the presence of quercetin and isoquercetin as well as protocatechuic, hydroxybenzoic, and coumaric acids and the activity of extracts as AChE and BChE inhibitors. It has also been shown that grain fragmentation affects the increase in the activity of seeds against cholinesterases (ChE). Furthermore, seeds have been shown to be a source of substances that inhibit microbial growth. Conclusions: It was found that the chia seed extracts are rich in polyphenols and inhibit the activity of ChEs; therefore, their use can be considered in further research in the field of treatment and prevention of neurodegenerative diseases.How to cite: Kobus-Cisowska J, Szymanowska D, Maciejewska P, et al. In vitro screening for acetylcholinesterase and butyrylcholinoesterase inhibition and antimicrobial activity of chia seeds (Salvia hispanica). Electron J Biotechnol 2019;37. https://doi.org/10.1016/j.ejbt.2018.10.002 Keywords: Acetylcholinesterase inhibition, Antimicrobial potential, Antioxidative properties, Butyrylcholinesterase inhibition, Chia seeds, Food additive, Phenolic acids and flavonols, Polyphenols, Prohealth, Salvia hispanicahttp://www.sciencedirect.com/science/article/pii/S0717345818300411 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Joanna Kobus-Cisowska Daria Szymanowska Paulina Maciejewska Dominik Kmiecik Anna Gramza-Michałowska Bartosz Kulczyński Judyta Cielecka-Piontek |
spellingShingle |
Joanna Kobus-Cisowska Daria Szymanowska Paulina Maciejewska Dominik Kmiecik Anna Gramza-Michałowska Bartosz Kulczyński Judyta Cielecka-Piontek In vitro screening for acetylcholinesterase and butyrylcholinesterase inhibition and antimicrobial activity of chia seeds (Salvia hispanica) Electronic Journal of Biotechnology |
author_facet |
Joanna Kobus-Cisowska Daria Szymanowska Paulina Maciejewska Dominik Kmiecik Anna Gramza-Michałowska Bartosz Kulczyński Judyta Cielecka-Piontek |
author_sort |
Joanna Kobus-Cisowska |
title |
In vitro screening for acetylcholinesterase and butyrylcholinesterase inhibition and antimicrobial activity of chia seeds (Salvia hispanica) |
title_short |
In vitro screening for acetylcholinesterase and butyrylcholinesterase inhibition and antimicrobial activity of chia seeds (Salvia hispanica) |
title_full |
In vitro screening for acetylcholinesterase and butyrylcholinesterase inhibition and antimicrobial activity of chia seeds (Salvia hispanica) |
title_fullStr |
In vitro screening for acetylcholinesterase and butyrylcholinesterase inhibition and antimicrobial activity of chia seeds (Salvia hispanica) |
title_full_unstemmed |
In vitro screening for acetylcholinesterase and butyrylcholinesterase inhibition and antimicrobial activity of chia seeds (Salvia hispanica) |
title_sort |
in vitro screening for acetylcholinesterase and butyrylcholinesterase inhibition and antimicrobial activity of chia seeds (salvia hispanica) |
publisher |
Elsevier |
series |
Electronic Journal of Biotechnology |
issn |
0717-3458 |
publishDate |
2019-01-01 |
description |
Background: Chia seeds are gaining increasing interest among food producers and consumers because of their prohealth properties. Results: The aim of this work was to evaluate the potential of chia seeds to act as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. The highest inhibitory activity against AChE and BChE was observed for colored seed ethanol extracts. A positive correlation was found between the presence of quercetin and isoquercetin as well as protocatechuic, hydroxybenzoic, and coumaric acids and the activity of extracts as AChE and BChE inhibitors. It has also been shown that grain fragmentation affects the increase in the activity of seeds against cholinesterases (ChE). Furthermore, seeds have been shown to be a source of substances that inhibit microbial growth. Conclusions: It was found that the chia seed extracts are rich in polyphenols and inhibit the activity of ChEs; therefore, their use can be considered in further research in the field of treatment and prevention of neurodegenerative diseases.How to cite: Kobus-Cisowska J, Szymanowska D, Maciejewska P, et al. In vitro screening for acetylcholinesterase and butyrylcholinoesterase inhibition and antimicrobial activity of chia seeds (Salvia hispanica). Electron J Biotechnol 2019;37. https://doi.org/10.1016/j.ejbt.2018.10.002 Keywords: Acetylcholinesterase inhibition, Antimicrobial potential, Antioxidative properties, Butyrylcholinesterase inhibition, Chia seeds, Food additive, Phenolic acids and flavonols, Polyphenols, Prohealth, Salvia hispanica |
url |
http://www.sciencedirect.com/science/article/pii/S0717345818300411 |
work_keys_str_mv |
AT joannakobuscisowska invitroscreeningforacetylcholinesteraseandbutyrylcholinesteraseinhibitionandantimicrobialactivityofchiaseedssalviahispanica AT dariaszymanowska invitroscreeningforacetylcholinesteraseandbutyrylcholinesteraseinhibitionandantimicrobialactivityofchiaseedssalviahispanica AT paulinamaciejewska invitroscreeningforacetylcholinesteraseandbutyrylcholinesteraseinhibitionandantimicrobialactivityofchiaseedssalviahispanica AT dominikkmiecik invitroscreeningforacetylcholinesteraseandbutyrylcholinesteraseinhibitionandantimicrobialactivityofchiaseedssalviahispanica AT annagramzamichałowska invitroscreeningforacetylcholinesteraseandbutyrylcholinesteraseinhibitionandantimicrobialactivityofchiaseedssalviahispanica AT bartoszkulczynski invitroscreeningforacetylcholinesteraseandbutyrylcholinesteraseinhibitionandantimicrobialactivityofchiaseedssalviahispanica AT judytacieleckapiontek invitroscreeningforacetylcholinesteraseandbutyrylcholinesteraseinhibitionandantimicrobialactivityofchiaseedssalviahispanica |
_version_ |
1725407228188426240 |