In-vivo monitoring of anti-folate therapy in arthritic rats using [18F]fluoro-PEG-folate and positron emission tomography

In-vivo monitoring of anti-folate therapy in arthritic rats using [18F]fluoro-PEG-folate and positron emission tomography

Abstract Background Folate receptor β (FRβ) is involved in facilitating cellular uptake of folates and anti-folates (such as methotrexate (MTX)). In rheumatoid arthritis, FRβ is expressed on synovial macrophages and recently has been explored as a biomarker for imaging in arthritic rats using the fo...

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Bibliographic Details
Main Authors: Durga M. S. H. Chandrupatla, Gerrit Jansen, Ricardo Vos, Mariska Verlaan, Qingshou Chen, Philip S. Low, Albert D. Windhorst, Adriaan A. Lammertsma, Conny J. van der Laken, Carla F. M. Molthoff
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Arthritis Research & Therapy
Subjects:
[18F]fluoro-PEG-folate
Folate receptor β
Methotrexate
Rheumatoid arthritis
Macrophages
Online Access:http://link.springer.com/article/10.1186/s13075-017-1325-x

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http://link.springer.com/article/10.1186/s13075-017-1325-x

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