Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition

Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition

The C. elegans LIN-41 and its homologs, including human TRIM71/LIN41, contain the RNA binding NHL domain. Here the authors combine computational analysis, structural biology and in vivo studies, to explain how these proteins bind RNA and how rapid evolution of NHL domains resulted in different solut...

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Bibliographic Details
Main Authors: Pooja Kumari, Florian Aeschimann, Dimos Gaidatzis, Jeremy J. Keusch, Pritha Ghosh, Anca Neagu, Katarzyna Pachulska-Wieczorek, Janusz M. Bujnicki, Heinz Gut, Helge Großhans, Rafal Ciosk
Format: Article
Language:English
Published: Nature Publishing Group 2018-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03920-7

Internet

https://doi.org/10.1038/s41467-018-03920-7

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