1-O-Acetylgeopyxin A, a derivative of a fungal metabolite, blocks tetrodotoxin-sensitive voltage-gated sodium, calcium channels and neuronal excitability which correlates with inhibition of neuropathic pain

1-O-Acetylgeopyxin A, a derivative of a fungal metabolite, blocks tetrodotoxin-sensitive voltage-gated sodium, calcium channels and neuronal excitability which correlates with inhibition of neuropathic pain

Abstract Chronic pain can be the result of an underlying disease or condition, medical treatment, inflammation, or injury. The number of persons experiencing this type of pain is substantial, affecting upwards of 50 million adults in the United States. Pharmacotherapy of most of the severe chronic p...

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Bibliographic Details
Main Authors: Yuan Zhou, Song Cai, Kimberly Gomez, E. M. Kithsiri Wijeratne, Yingshi Ji, Shreya S. Bellampalli, Shizhen Luo, Aubin Moutal, A. A. Leslie Gunatilaka, Rajesh Khanna
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Molecular Brain
Subjects:
1-O-acetylgeopyxin a
Voltage-gated calcium channels
Voltage-gated sodium channels
Tetrodotoxin-sensitive voltage-gated sodium channels
Excitability
Non-opioid pain-relieving therapeutics
Online Access:http://link.springer.com/article/10.1186/s13041-020-00616-2

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http://link.springer.com/article/10.1186/s13041-020-00616-2

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