B cells negatively regulate the establishment of CD49b+T-bet+ resting memory T helper cells in the bone marrow

B cells negatively regulate the establishment of CD49b+T-bet+ resting memory T helper cells in the bone marrow

During an immune reaction, some antigen-experienced CD4 T cells relocate from secondary lymphoid organs (SLOs) to the bone marrow (BM) in a CD49b-dependent manner and reside and rest there as professional memory CD4 T cells. However, it remains unclear how the precursors of BM memory CD4 T cells are...

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Bibliographic Details
Main Authors: Shintaro eHojyo, Jana eSarkander, Christian eMaenne, Mathias eMursell, Asami eHanazawa, David eZimmel, Jinfang eZhu, William E Paul, Simon eFillatreau, Max eLöhning, Andreas eRadbruch, Koji eTokoyoda
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Immunology
Subjects:
Bone Marrow
B cells
T-bet
CD49b
Resting memory
CD4 T helper cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00026/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00026/full

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