Docosahexaenoic acid supplementation fully restores fertility and spermatogenesis in male delta-6 desaturase-null mice

Docosahexaenoic acid supplementation fully restores fertility and spermatogenesis in male delta-6 desaturase-null mice

Delta-6 desaturase-null mice (−/−) are unable to synthesize highly unsaturated fatty acids (HUFAs): arachidonic acid (AA), docosahexaenoic acid (DHA), and n6-docosapentaenoic acid (DPAn6). The −/− males exhibit infertility and arrest of spermatogenesis at late spermiogenesis. To determine which HUFA...

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Bibliographic Details
Main Authors: Manuel Roqueta-Rivera, Chad K. Stroud, Wanda M. Haschek, Sandeep J. Akare, Mariangela Segre, Richard S. Brush, Martin-Paul Agbaga, Robert E. Anderson, Rex A. Hess, Manabu T. Nakamura
Format: Article
Language:English
Published: Elsevier 2010-02-01
Series:Journal of Lipid Research
Subjects:
essential fatty acids
arachidonic acid
highly unsaturated fatty acids
very-long-chain polyunsaturated fatty acids
choelsta-3,5-diene
male reproduction
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520305411

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http://www.sciencedirect.com/science/article/pii/S0022227520305411

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