Identification of Glycine Receptor α3 as a Colchicine-Binding Protein

Identification of Glycine Receptor α3 as a Colchicine-Binding Protein

Colchicine (Col) is considered a kind of highly effective alkaloid for preventing and treating acute gout attacks (flares). However, little is known about the underlying mechanism of Col in pain treatment. We have previously developed a customized virtual target identification method, termed IFPTarg...

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Bibliographic Details
Main Authors: Xikun Zhou, Mingbo Wu, Yongmei Xie, Guo-Bo Li, Tao Li, Rou Xie, Kailun Wang, Yige Zhang, Chaoyu Zou, Wenling Wu, Qi Wang, Xiangwei Wang, Ximu Zhang, Jiong Li, Jing Li, Yu-Quan Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
colchicine
glycine receptor alpha 3
inflammatory pain
gouty arthritis
virtual target identification
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01238/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01238/full

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