Immunosuppressant MPA Modulates Tight Junction through Epigenetic Activation of MLCK/MLC-2 Pathway via p38MAPK

Immunosuppressant MPA Modulates Tight Junction through Epigenetic Activation of MLCK/MLC-2 Pathway via p38MAPK

Background: Mycophenolic acid (MPA) is an important immunosuppressive drug (ISD) prescribed to prevent graft rejection in the organ transplanted patients, however, its use is also associated with adverse side effects like sporadic gastrointestinal (GI) disturbances. Recently, we reported the MPA ind...

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Bibliographic Details
Main Authors: Niamat Khan, D. V. Krishna Pantakani, Lutz Binder, Muhammad Qasim, Abdul R. Asif
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-12-01
Series:Frontiers in Physiology
Subjects:
tight junction
permeability
MPA
epigenetic
promoter activity
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2015.00381/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2015.00381/full

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