Transcriptome Analysis in a Mouse Model of Premature Aging of Dentate Gyrus: Rescue of Alpha-Synuclein Deficit by Virus-Driven Expression or by Running Restores the Defective Neurogenesis

Transcriptome Analysis in a Mouse Model of Premature Aging of Dentate Gyrus: Rescue of Alpha-Synuclein Deficit by Virus-Driven Expression or by Running Restores the Defective Neurogenesis

The dentate gyrus of the hippocampus and the subventricular zone are neurogenic niches where neural stem and progenitor cells replicate throughout life to generate new neurons. The Btg1 gene maintains the stem cells of the neurogenic niches in quiescence. The deletion of Btg1 leads to an early trans...

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Bibliographic Details
Main Authors: Laura Micheli, Teresa Maria Creanza, Manuela Ceccarelli, Giorgio D’Andrea, Giacomo Giacovazzo, Nicola Ancona, Roberto Coccurello, Raffaella Scardigli, Felice Tirone
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
adult neurogenesis
aging
dentate gyrus
neural stem cells
self-renewal
alpha-synuclein (Snca)
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.696684/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.696684/full

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