Viral RNA-dependent RNA polymerase mutants display an altered mutation spectrum resulting in attenuation in both mosquito and vertebrate hosts.

Viral RNA-dependent RNA polymerase mutants display an altered mutation spectrum resulting in attenuation in both mosquito and vertebrate hosts.

The presence of bottlenecks in the transmission cycle of many RNA viruses leads to a severe reduction of number of virus particles and this occurs multiple times throughout the viral transmission cycle. Viral replication is then necessary for regeneration of a diverse mutant swarm. It is now underst...

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Bibliographic Details
Main Authors: K Lane Warmbrod, Edward I Patterson, Tiffany F Kautz, Adam Stanton, Dedeke Rockx-Brouwer, Birte K Kalveram, Kamil Khanipov, Saravanan Thangamani, Yuriy Fofanov, Naomi L Forrester
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-04-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC6467425?pdf=render

Internet

http://europepmc.org/articles/PMC6467425?pdf=render

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