Evidence for formation of hydroxyl radicals during reperfusion after global cerebral ischaemia in rats using salicylate trapping and microdialysis
Systemic administration of salicylate (SA) to rats (100 mg kg−1i.p.) was used as anin vivotrap of hydroxyl radicals (·OH). In the brain SA reacts with hydroxyl radicals to form the stable adducts 2,3- and 2,5 dihydroxybenzoic acid (DHBAs) which can thus be taken as an index of·OH formation. The DHBA...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
1994-12-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996184700167 |