Deferasirox-Dependent Iron Chelation Enhances Mitochondrial Dysfunction and Restores p53 Signaling by Stabilization of p53 Family Members in Leukemic Cells

Deferasirox-Dependent Iron Chelation Enhances Mitochondrial Dysfunction and Restores p53 Signaling by Stabilization of p53 Family Members in Leukemic Cells

I<i>ron</i> is crucial to satisfy several mitochondrial functions including energy metabolism and oxidative phosphorylation. Patients affected by Myelodysplastic Syndromes (MDS) and acute myeloid leukemia (AML) are frequently characterized by iron overload (IOL), due to continuous red bl...

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Bibliographic Details
Main Authors: Chiara Calabrese, Cristina Panuzzo, Serena Stanga, Giacomo Andreani, Silvia Ravera, Alessandro Maglione, Lucrezia Pironi, Jessica Petiti, Muhammad Shahzad Shahzad Ali, Patrizia Scaravaglio, Francesca Napoli, Carmen Fava, Marco De De Gobbi, Francesco Frassoni, Giuseppe Saglio, Enrico Bracco, Barbara Pergolizzi, Daniela Cilloni
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
iron
Deferasirox
chelation
leukemia
mitochondria
p21
Online Access:https://www.mdpi.com/1422-0067/21/20/7674

Internet

https://www.mdpi.com/1422-0067/21/20/7674

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