Macrophage Activation-Like Syndrome: A Distinct Entity Leading to Early Death in Sepsis

Macrophage Activation-Like Syndrome: A Distinct Entity Leading to Early Death in Sepsis

Hemophagocytic lymphohistocytosis (HLH) is characterized by fulminant cytokine storm leading to multiple organ dysfunction and high mortality. HLH is classified into familial (fHLH) and into secondary (sHLH). fHLH is rare and it is due to mutations of genes encoding for perforin or excretory granule...

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Bibliographic Details
Main Authors: Eleni Karakike, Evangelos J. Giamarellos-Bourboulis
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
macrophage activation syndrome
sepsis
hemophagocytic lymphohistocytosis
ferritin
interleukins
interferon-gamma
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00055/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00055/full

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