What Binds Cationic Photosensitizers Better: Brownian Dynamics Reveals Key Interaction Sites on Spike Proteins of SARS-CoV, MERS-CoV, and SARS-CoV-2

What Binds Cationic Photosensitizers Better: Brownian Dynamics Reveals Key Interaction Sites on Spike Proteins of SARS-CoV, MERS-CoV, and SARS-CoV-2

We compared the electrostatic properties of the spike proteins (S-proteins) of three coronaviruses, SARS-CoV, MERS-CoV, and SARS-CoV-2, and their interactions with photosensitizers (PSs), octacationic octakis(cholinyl)zinc phthalocyanine (Zn-PcChol<sub>8+</sub>) and monocationic methylen...

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Bibliographic Details
Main Authors: Vladimir Fedorov, Ekaterina Kholina, Sergei Khruschev, Ilya Kovalenko, Andrew Rubin, Marina Strakhovskaya
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Viruses
Subjects:
SARS-CoV
SARS-CoV-2
MERS-CoV
spike protein
photosensitizer
octakis(cholinyl)zinc phthalocyanine
Online Access:https://www.mdpi.com/1999-4915/13/8/1615

Internet

https://www.mdpi.com/1999-4915/13/8/1615

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