iRGD-guided tamoxifen polymersomes inhibit estrogen receptor transcriptional activity and decrease the number of breast cancer cells with self-renewing capacity

iRGD-guided tamoxifen polymersomes inhibit estrogen receptor transcriptional activity and decrease the number of breast cancer cells with self-renewing capacity

Abstract Background Tamoxifen (Tam) is the most frequent treatment for estrogen receptor (ER) positive breast cancer. We recently showed that fibronectin (FN) leads to Tam resistance and selection of breast cancer stem cells. With the aim of developing a nanoformulation that would simultaneously tac...

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Bibliographic Details
Main Authors: María Inés Diaz Bessone, Lorena Simón-Gracia, Pablo Scodeller, María de los Angeles Ramirez, María Amparo Lago Huvelle, Galo J. A. A. Soler-Illia, Marina Simian
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Nanobiotechnology
Subjects:
Breast cancer
Tamoxifen
Endocrine resistance
Fibronectin
iRGD-guided polymersomes
Self-renewing capacity
Online Access:https://doi.org/10.1186/s12951-019-0553-4

Internet

https://doi.org/10.1186/s12951-019-0553-4

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