Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis

Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis

Cellular proliferation depends on refilling the tricarboxylic acid (TCA) cycle to support biomass production (anaplerosis). The two major anaplerotic pathways in cells are pyruvate conversion to oxaloacetate via pyruvate carboxylase (PC) and glutamine conversion to α-ketoglutarate. Cancers often sho...

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Bibliographic Details
Main Authors: Stefan Christen, Doriane Lorendeau, Roberta Schmieder, Dorien Broekaert, Kristine Metzger, Koen Veys, Ilaria Elia, Joerg Martin Buescher, Martin Franz Orth, Shawn Michael Davidson, Thomas Georg Philipp Grünewald, Katrien De Bock, Sarah-Maria Fendt
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Cell Reports
Subjects:
pyruvate carboxylase
mitochondrial pyruvate concentration
lung metastasis
breast cancer
TCA cycle anaplerosis
microenvironment
glycolytic metabolism
cancer metabolism
13C tracer analysis
pyruvate metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716312815

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http://www.sciencedirect.com/science/article/pii/S2211124716312815

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