Identification of Mutation Regions on NF1 Responsible for High- and Low-Risk Development of Optic Pathway Glioma in Neurofibromatosis Type I

Identification of Mutation Regions on NF1 Responsible for High- and Low-Risk Development of Optic Pathway Glioma in Neurofibromatosis Type I

Neurofibromatosis type I is a rare neurocutaneous syndrome resulting from loss-of-function mutations of NF1. The present study sought to determine a correlation between mutation regions on NF1 and the risk of developing optic pathway glioma (OPG) in patients with neurofibromatosis type I. A total of...

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Bibliographic Details
Main Authors: Min Xu, Hui Xiong, Yanfang Han, Chijun Li, Shaozhen Mai, Zhongzhou Huang, Xuechen Ai, Zhixuan Guo, Fanqin Zeng, Qing Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Genetics
Subjects:
neurofibromatosis type I
NF1
genotype
mutation
optic pathway glioma
phenotype
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00270/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2018.00270/full

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