Allograft Inflammatory Factor-1 Governs Hematopoietic Stem Cell Differentiation Into cDC1 and Monocyte-Derived Dendritic Cells Through IRF8 and RelB in vitro

Allograft Inflammatory Factor-1 Governs Hematopoietic Stem Cell Differentiation Into cDC1 and Monocyte-Derived Dendritic Cells Through IRF8 and RelB in vitro

The multistep differentiation process from hematopoietic stem cells through common myeloid progenitors into committed dendritic cell (DC) subsets remains to be fully addressed. These studies now show that Allograft Inflammatory Factor-1 (AIF1) is required for differentiation of classical DC type 1 (...

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Bibliographic Details
Main Authors: Diana M. Elizondo, Nailah Z. D. Brandy, Ricardo L. L. da Silva, Naomi L. Haddock, Apollo D. Kacsinta, Tatiana R. de Moura, Michael W. Lipscomb
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
dendritic cells
allograft inflammatory factor 1
hematopoietic stem cells
cDC1 dendritic cells
monocyte-derived DC
RelB/NFκB
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00173/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00173/full

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