Human cancer cells retain modest levels of enzymatically active matriptase only in extracellular milieu following induction of zymogen activation.

Human cancer cells retain modest levels of enzymatically active matriptase only in extracellular milieu following induction of zymogen activation.

The type 2 transmembrane serine protease matriptase is broadly expressed in human carcinomas and hematological cancers. The proteolytic activity of matriptase is a potential target of drugs and imaging probes. We assessed the fate of active matriptase following the induction of matriptase zymogen ac...

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Bibliographic Details
Main Authors: Li-Ling Chu, Yuan Xu, Jie-Ru Yang, Yi-An Hu, Hsiang-Hua Chang, Hong-Yu Lai, Chun-Che Tseng, Hue-Yu Wang, Michael D Johnson, Jehng-Kang Wang, Chen-Yong Lin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3963879?pdf=render

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http://europepmc.org/articles/PMC3963879?pdf=render

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