Endoplasmic reticulum stress and inflammation in the central nervous system
Abstract Persistent endoplasmic reticulum (ER) stress is thought to drive the pathology of many chronic disorders due to its potential to elicit aberrant inflammatory signaling and facilitate cell death. In neurodegenerative diseases, the accumulation of misfolded proteins and concomitant induction...
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doaj-5ab4b0dedef049549607f178396ecd732020-11-24T21:11:45ZengBMCMolecular Neurodegeneration1750-13262017-05-0112111810.1186/s13024-017-0183-yEndoplasmic reticulum stress and inflammation in the central nervous systemNeil T. Sprenkle0Savannah G. Sims1Cristina L. Sánchez2Gordon P. Meares3Department of Microbiology, Immunology and Cell Biology, West Virginia University School of MedicineDepartment of Microbiology, Immunology and Cell Biology, West Virginia University School of MedicineDepartment of Microbiology, Immunology and Cell Biology, West Virginia University School of MedicineDepartment of Microbiology, Immunology and Cell Biology, West Virginia University School of MedicineAbstract Persistent endoplasmic reticulum (ER) stress is thought to drive the pathology of many chronic disorders due to its potential to elicit aberrant inflammatory signaling and facilitate cell death. In neurodegenerative diseases, the accumulation of misfolded proteins and concomitant induction of ER stress in neurons contributes to neuronal dysfunction. In addition, ER stress responses induced in the surrounding neuroglia may promote disease progression by coordinating damaging inflammatory responses, which help fuel a neurotoxic milieu. Nevertheless, there still remains a gap in knowledge regarding the cell-specific mechanisms by which ER stress mediates neuroinflammation. In this review, we will discuss recently uncovered inflammatory pathways linked to the ER stress response. Moreover, we will summarize the present literature delineating how ER stress is generated in Alzheimer’s disease, Parkinson’s disease, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis, and highlight how ER stress and neuroinflammation intersect mechanistically within the central nervous system. The mechanisms by which stress-induced inflammation contributes to the pathogenesis and progression of neurodegenerative diseases remain poorly understood. Further examination of this interplay could present unappreciated insights into the development of neurodegenerative diseases, and reveal new therapeutic targets.http://link.springer.com/article/10.1186/s13024-017-0183-yEndoplasmic reticulum stressUnfolded protein responseNeuroinflammationNeurodegeneration |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Neil T. Sprenkle Savannah G. Sims Cristina L. Sánchez Gordon P. Meares |
spellingShingle |
Neil T. Sprenkle Savannah G. Sims Cristina L. Sánchez Gordon P. Meares Endoplasmic reticulum stress and inflammation in the central nervous system Molecular Neurodegeneration Endoplasmic reticulum stress Unfolded protein response Neuroinflammation Neurodegeneration |
author_facet |
Neil T. Sprenkle Savannah G. Sims Cristina L. Sánchez Gordon P. Meares |
author_sort |
Neil T. Sprenkle |
title |
Endoplasmic reticulum stress and inflammation in the central nervous system |
title_short |
Endoplasmic reticulum stress and inflammation in the central nervous system |
title_full |
Endoplasmic reticulum stress and inflammation in the central nervous system |
title_fullStr |
Endoplasmic reticulum stress and inflammation in the central nervous system |
title_full_unstemmed |
Endoplasmic reticulum stress and inflammation in the central nervous system |
title_sort |
endoplasmic reticulum stress and inflammation in the central nervous system |
publisher |
BMC |
series |
Molecular Neurodegeneration |
issn |
1750-1326 |
publishDate |
2017-05-01 |
description |
Abstract Persistent endoplasmic reticulum (ER) stress is thought to drive the pathology of many chronic disorders due to its potential to elicit aberrant inflammatory signaling and facilitate cell death. In neurodegenerative diseases, the accumulation of misfolded proteins and concomitant induction of ER stress in neurons contributes to neuronal dysfunction. In addition, ER stress responses induced in the surrounding neuroglia may promote disease progression by coordinating damaging inflammatory responses, which help fuel a neurotoxic milieu. Nevertheless, there still remains a gap in knowledge regarding the cell-specific mechanisms by which ER stress mediates neuroinflammation. In this review, we will discuss recently uncovered inflammatory pathways linked to the ER stress response. Moreover, we will summarize the present literature delineating how ER stress is generated in Alzheimer’s disease, Parkinson’s disease, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis, and highlight how ER stress and neuroinflammation intersect mechanistically within the central nervous system. The mechanisms by which stress-induced inflammation contributes to the pathogenesis and progression of neurodegenerative diseases remain poorly understood. Further examination of this interplay could present unappreciated insights into the development of neurodegenerative diseases, and reveal new therapeutic targets. |
topic |
Endoplasmic reticulum stress Unfolded protein response Neuroinflammation Neurodegeneration |
url |
http://link.springer.com/article/10.1186/s13024-017-0183-y |
work_keys_str_mv |
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